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Not recommended for people who are caffeine sensitive, children under 18, or women pregnant or nursing

a ) Graphical view of the viral vector carrying EGFP followed by a lox-stop-lox preceding the Gsto2 -shRNA or scrambled to allow expression only in cells carrying Cre recombinase

DCA has been described as an allosteric PDK inhibitor that, at mM concentration (IC50) and in concomitance with ADP, binds to the pyruvate pocket of the PDK complex enzyme, avoiding attachment of the kinase domain to the E2 domain 55,56

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